Cross-Institutional Federated Healthcare Analytics
Keywords:
Federated Learning,Privacy-Preserving Machine Learning,Secure Multi-Party Computation (SMPC),Healthcare Data Collaboration,Distributed AI Systems,Differential Privacy,Data Governance in Healthcare,Secure Model Aggregation,Cross-Institutional Data Analysis,Homomorphic Encryption,Decentralized Machine Learning,Clinical Data Sharing Frameworks,Privacy-Aware AI Architectures,Interoperable Healthcare Systems,Trustworthy AI in Healthcare.Abstract
The difficulties of working in sectors with strict privacy constraints, such as healthcare, result from the fact that data is separated and distributed across multiple sources that are unable to exchange it. The solution to this dilemma is to allow multiple data owners to collaborate on a joint task by using shared/global models while keeping the data decentralized. Three paradigms of federated machine learning are proposed: horizontal federated learning, vertical federated learning, and federated transfer learning. Federated learning processes and architectures with privacy-preserving properties that also address data provenance, access control, and interoperability.
Integrating heterogeneous distributed data sources while maintaining privacy is a major challenge for modern data and AI analysis. Sensitive data in particular, such as healthcare data, privacy is guaranteed by law. Therefore, many healthcare data sources are available based on these data sharing and data monetization are a difficult integration task. Multiple organizations are willing to collaborate by sharing insights from their private datasets, but without sharing the original datasets because healthcare data is highly sensitive. However, existing guidelines permit the use of healthcare data in Europe and America only for either research or health benefits, and not even for commercial use. Nevertheless, several companies are attempting to break this barrier by using fake-generated data for AI modeling purposes. As a result, three main criteria must be considered during the establishment of collaboration for multi-organization AI data modeling: privacy, security, and monitoring.
References
1. Dayan, I., Roth, H. R., Zhong, A., Harouni, A., Gentili, A., Abidin, A. Z., Liu, A., Costa, A. B., Wood, B. J., Tsai, C.-S., & others. (2021). Federated learning for predicting clinical outcomes in patients with COVID-19. Nature Medicine, 27, 1735–1743.
2. Sadilek, A., Liu, L., Nguyen, D., Kamruzzaman, M., Serghiou, S., Rader, B., Ingerman, A., Mellem, S., Kairouz, P., Nsoesie, E. O., MacFarlane, J., Vullikanti, A., Marathe, M., Eastham, P., Brownstein, J. S., Aguera y Arcas, B., Howell, M. D., & Hernandez, J. (2021). Privacy-first health research with federated learning. npj Digital Medicine, 4, 132.
3. Warnat-Herresthal, S., Schultze, H., Shastry, K. L., Manamohan, S., Mukherjee, S., Garg, V., Sarveswara, R., et al. (2021). Swarm Learning for decentralized and confidential clinical machine learning. Nature, 594, 265–270.
4. Rieke, N., Hancox, J., Li, W., Milletari, F., Roth, H. R., Albarqouni, S., Bakas, S., Galtier, M. N., Landman, B. A., Maier-Hein, K., Ourselin, S., Sheller, M., Summers, R. M., Trask, A., Xu, D., Baust, M., & Cardoso, M. J. (2021). The future of digital health with federated learning. npj Digital Medicine, 3, 119.
5. Kolla, S. H., & Peddi, R. K. (2024). Designing Governance-Aligned GenAI Pipelines Using Small Language Models for Enterprise Workflow Intelligence. International Journal of Science, Research and Technology, 7(6), 13256-13268.
6. Pati, S., Baid, U., Edwards, B., Sheller, M. J., Wang, S.-H., Reina, G. A., Foley, W. D., Gruzdev, A., Tannenbaum, A., Thakur, S. P., et al. (2021). Federated learning enables big data for rare cancer boundary detection. Nature Communications, 12, 3020.
7. FAMHE research team. (2021). Truly privacy-preserving federated analytics for precision medicine with multiparty homomorphic encryption. Nature Communications, 12, 5910.
8. Guo, P., Wang, P., Zhou, J., Jiang, S., & Patel, V. M. (2021). Multi-institutional collaborations for improving deep learning-based magnetic resonance image reconstruction using federated learning. Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, 2423–2432.
9. Glicksberg, B. S., Celi, L. A., & others. (2021). Federated learning of electronic health records to improve mortality prediction in hospitalized patients with COVID-19: Machine learning approach. JMIR Medical Informatics, 9(1), e24207.
10. Crowson, M. G., Moukheiber, D., Robles Arévalo, A., Lam, B. D., Mantena, S., Rana, A., Goss, D., Bates, D. W., & Celi, L. A. (2022). A systematic review of federated learning applications for biomedical data. PLOS Digital Health, 1(5), e0000033.
11. Adnan, M., Kalra, S., Cresswell, J. C., Taylor, G. W., & Tizhoosh, H. R. (2022). Federated learning and differential privacy for medical image analysis. Scientific Reports, 12, 1953.
12. Linardos, A., Kushibar, K., Walsh, S., Gkontra, P., & Lekadir, K. (2022). Federated learning for multi-center imaging diagnostics: A simulation study in cardiovascular disease. Scientific Reports, 12, 3551.
13. Mattaparthi, R. (2024). Transformer-Based Fault Diagnosis for Large-Scale Standby Power Generators: Partial Discharge Pattern Recognition at Hyperscale Data Center Installations. Journal of Computational Analysis and Applications (JoCAAA), 33(08), 8781-8799.
14. Nguyen, T. V., Dakka, M. A., Diakiw, S. M., VerMilyea, M. D., Perugini, M., Hall, J. M. M., & Perugini, D. (2022). A novel decentralized federated learning approach to train on globally distributed, poor quality, and protected private medical data. Scientific Reports, 12, 8888.
15. Wang, W., Li, X., Qiu, X., Zhang, X., Brusic, V., & Zhao, J. (2023). A privacy preserving framework for federated learning in smart healthcare systems. Information Processing & Management, 60(1), 103167.
16. Rajendran, S., et al. (2023). Data heterogeneity in federated learning with electronic health records: Case studies of risk prediction for acute kidney injury and sepsis diseases in critical care. PLOS Digital Health, 2(3), e0000117.
17. Zhao, L., & Huang, J. (2023). A distribution information sharing federated learning approach for medical image data. Complex & Intelligent Systems, 9, 5625–5636.
18. Rajagopal, A., Redekop, E., et al. (2023). Federated learning with research prototypes: Application to multi-center MRI-based detection of prostate cancer with diverse histopathology. Academic Radiology, 30(4), 644–657.
19. Ma, B., Feng, Y., Chen, G., Li, C., & Xia, Y. (2023). Federated adaptive reweighting for medical image classification. Pattern Recognition, 144, 109880.
20. Reddy, V. A. R. (2024). Generative Intelligence for Healthcare Claims Processing and Personalized Benefits Management. International Journal of Advanced Engineering Science and Information Technology (IJAESIT), 7(3), 14099.
21. Liu, Z., Wu, F., Wang, Y., Yang, M., & Pan, X. (2023). FedCL: Federated contrastive learning for multi-center medical image classification. Pattern Recognition, 143, 109739.
22. Sandhu, S. S., Gorji, H. T., Tavakolian, P., Tavakolian, K., & Akhbardeh, A. (2023). Medical imaging applications of federated learning. Diagnostics, 13(19), 3140.
23. Rehman, M. H. U., Pinaya, W. H. L., Nachev, P., & Teo, J. T. (2023). Federated learning for medical imaging radiology. The British Journal of Radiology, 96(1150), 20220890.
24. Noman, A. A., Rahaman, M., Pranto, T. H., & Rahman, R. M. (2023). Blockchain for medical collaboration: A federated learning-based approach for multi-class respiratory disease classification. Healthcare Analytics, 3, 100135.
25. Nagaraj, D., Khandelwal, P., Steyaert, S., & Gevaert, O. (2023). Augmenting digital twins with federated learning in medicine. The Lancet Digital Health, 5(5), e251–e253.
26. Aravind, R. (2024). Integrating controller area network (CAN) with cloud-based data storage solutions for improved vehicle diagnostics using AI. Educational Administration: Theory and Practice, 30(1), 992-1005.
27. Guan, H., Yap, P.-T., Bozoki, A., & Liu, M. (2024). Federated learning for medical image analysis: A survey. Pattern Recognition, 151, 110424.
28. Pati, S., Kumar, S., Varma, A., et al. (2024). Privacy preservation for federated learning in health care. Patterns, 5(7), 100974.
29. Soltan, A. A. S., Thakur, A., Yang, J., Chauhan, A., D’Cruz, L. G., Dickson, P., Soltan, M. A., Thickett, D. R., Eyre, D. W., Zhu, T., & Clifton, D. A. (2024). A scalable federated learning solution for secondary care using low-cost microcomputing: Privacy-preserving development and evaluation of a COVID-19 screening test in UK hospitals. The Lancet Digital Health, 6(2), e93–e104.
Additional Files
Published
Issue
Section
License
Copyright (c) 2025 Ghatoth mishra (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.
The American Online Journal of Science and Engineering (AOJSE) is an open-access journal, and all published articles are made freely available to readers worldwide under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license governs the use, sharing, adaptation, and distribution of all content published in AOJSE and is designed to promote the broadest possible dissemination and reuse of scholarly research.
Creative Commons Attribution 4.0 International License (CC BY 4.0)
Under the Creative Commons Attribution 4.0 International License, any user is free to share, copy, and redistribute the published material in any medium or format, and to adapt, remix, transform, and build upon the material for any purpose, including commercial use, provided that appropriate credit is given to the original authors and source. The license cannot be revoked as long as the terms are followed.
When using or redistributing content published in AOJSE, users must provide proper attribution by citing the original authors' names, the article title, the journal name (AOJSE), the volume and issue number, the year of publication, and the DOI or URL of the article. Users must also indicate if any changes were made to the original work. Attribution must be provided in a reasonable manner but must not suggest that the authors or AOJSE endorse the user or their use of the material.
Author Rights and Copyright Retention
AOJSE respects and upholds the intellectual property rights of all contributing authors. Authors who publish in AOJSE retain full copyright over their work. By submitting a manuscript to AOJSE, authors grant the journal a non-exclusive, worldwide, royalty-free license to publish, reproduce, distribute, publicly display, and archive the article in print and electronic formats. This license allows AOJSE to make the article freely accessible to readers globally while ensuring that the authors remain the rightful owners of their work.
Authors are permitted to deposit their published articles in institutional repositories, personal websites, academic networking platforms, and preprint servers, provided that the original publication in AOJSE is acknowledged and properly cited. Authors may also reuse their published content in subsequent works, presentations, teaching materials, and grant applications without requiring prior permission from the journal.
Third-Party Content
Authors are solely responsible for obtaining written permission to reproduce any third-party material, including figures, tables, images, data, or excerpts from other publications, included in their manuscript. Evidence of such permissions must be provided to the editorial office upon request. AOJSE does not assume any responsibility for copyright infringement arising from the unauthorized inclusion of third-party content in published articles.
Permitted Uses
Under the CC BY 4.0 license, the following uses of AOJSE published content are freely permitted without prior written permission from the journal or authors, provided that proper attribution is given. Users may read, download, print, and distribute articles for personal, educational, or research purposes. Researchers may reuse data, figures, and findings for meta-analyses, systematic reviews, and secondary research. Educators may incorporate published articles into course materials, syllabi, and academic presentations. Journalists, policymakers, and practitioners may reference and cite published findings for professional and public interest purposes.
Prohibited Uses
While the CC BY 4.0 license is broad and permissive, users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits. Users may not misrepresent the original authorship of published content or imply endorsement by the original authors or AOJSE without explicit consent. Plagiarism, data fabrication, and any form of academic misconduct in the reuse of published material are strictly prohibited and are a violation of publication ethics standards.
Institutional and Repository Deposit Policy
AOJSE fully supports self-archiving and green open access. Authors are encouraged to deposit the final published version of their article, also known as the version of record, in institutional repositories, subject repositories, and open-access databases immediately upon publication. There is no embargo period. Authors should always link back to the original article on the AOJSE website and include the full citation and DOI when depositing their work in any repository.
Digital Preservation and Archiving
AOJSE is committed to the long-term digital preservation of all published content to ensure its permanent availability and accessibility. The journal utilizes the Open Journal Systems (OJS) platform, which supports internationally recognized digital archiving standards. AOJSE encourages participation in archiving networks such as LOCKSS (Lots of Copies Keep Stuff Safe) and CLOCKSS (Controlled LOCKSS) to safeguard published articles against data loss and ensure continued access for future generations of researchers and readers.
Disclaimer
The views, opinions, findings, and conclusions expressed in articles published in AOJSE are solely those of the authors and do not necessarily reflect the official position, policy, or views of the journal, its editorial board, or its affiliated organizations. AOJSE makes every effort to ensure the accuracy and integrity of published content but does not accept legal responsibility for any errors, omissions, or claims arising from the use of information published in the journal.
Contact for Licensing Inquiries
For any questions regarding the licensing terms, copyright, or permitted use of content published in AOJSE, please contact the editorial office through the journal website at https://aojse.org. The editorial team will be happy to assist authors, readers, and institutions with any licensing-related queries.